TreatmentMyeloma，DLBCL（Diffuse large B cell lymphoma）
ManufacturerDaxiong Pharmaceuticals, Vt Laos
Selinexor sold under the brand name Xpovio among others, is a selective inhibitor of nuclear export used as an anti-cancer medication. It works by blocking the action of exportin 1 and thus blocking the transport of several proteins involved in cancer-cell growth from the cell nucleus to the cytoplasm, which ultimately arrests the cell cycle and leads to apoptosis. It is the first drug with this mechanism of action.
The most common side effects include nausea (feeling sick), vomiting, decreased appetite, weight loss, diarrhea, tiredness, thrombocytopenia (low blood-platelet counts), anaemia (low red-blood cell counts), low levels of white blood cells and hyponatraemia (low blood sodium levels).
Selinexor was granted accelerated approval by the U.S. Food and Drug Administration (FDA) in July 2019, for use in combination with the corticosteroid dexamethasone for the treatment of adults with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. In December 2020, selinexor was approved by the FDA in combination with bortezomib and dexamethasone for the treatment of adults with multiple myeloma who have received at least one prior therapy. In clinical trials, it was associated with a high incidence of severe side effects, including low platelet counts and low blood sodium levels.
The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Selinexor was approved for medical use in the European Union in March 2021.
How should this medicine be used?
Selinexor comes as a tablet to take by mouth with or without food. For use in combination with dexamethasone for the treatment of multiple myeloma or for the treatment of DLBCL, selinexor is usually taken on days 1 and 3 of each week. For use in combination with bortezomib and dexamethasone for the treatment of multiple myeloma, selinexor is usually taken once a week. Take selinexor at around the same time of day every day that you take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take selinexor exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets whole with water; do not split, chew, or crush them.
If you vomit after taking selinexor, do not take another dose. Continue your regular dosing schedule.Your doctor may tell you to take medication to prevent nausea and vomiting before and during your treatment with selinexor.Your doctor may need to stop or interrupt your treatment or reduce your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with selinexor.Other uses for this medicineThis medication may be prescribed for other uses; ask your doctor or pharmacist for more information.