TreatmentEGFR Lung cancer
Quantity Unit100mg/Tablet , 4t/bottle
ManufacturerTongmeng (Lao) Pharmaceutical & Food Co., Ltd.
Trelagliptin trade name Trestin, Zafatek is a pharmaceutical drug used for the treatment of type 2 diabetes (diabetes mellitus).
It is a highly selective dipeptidyl peptidase-4 inhibitor that is typically used as an add on treatment when the first line treatment of metformin is not achieving the expected glycemic goals; though it has been approved for use as a first line treatment when metformin cannot be used.
DPP-4 inhibitors activate T-cells and are more commonly known as T-cell activation antigens (specifically CD26). Chemically, it is a fluorinated derivative of alogliptin.
Gliptins are thought to have cardiovascular protective abilities though the extent of these effects is still being studied.They are also being studied for the ability that this class of drugs has at promoting B-cell survival.
Administration and dosing
Chemical structure of trelagliptin succinate
Similar drugs in the same class as trelagliptin are administered once daily while trelagliptin is administered once weekly. Alogliptin (Nesina) is the other major DPP-4 inhibitor on the market. It is also owned by Takeda and is administered once daily. A dosing of once per week is advantageous as a reduction in the frequency of required dosing is known to increase patient compliance. A recent meta-analysis published by Dutta et. al. highlighted the good glycaemic efficacy and safety of this molecule as compared to peer DPP4 inhibitors which have to be taken daily like alogliptin, sitagliptin, linagliptin, teneligliptin, anagliptin or vildagliptin, having an advantage of reducing the monthly pill count from 30 to 4.