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Larotreni (Larotrectinib)

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Model Number：

RL1420230901296990
Brand Name：

Larotreni 25&100
Origin：

Generic drug，Laos
Small Orders：

Small batches also available
Tags：

NTRK gene fusion-positive solid tumors NTRK fusion-positive solid tumors

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Poster

Details
Description

Packaging Size

60C/bottle
Strength

25mg&100mg
Compositon

Larotrectinib
Treatment

Neurotrophic tyrosine receptor kinase (NTRK) gene fusion solid tumors
Form

Capsule
Brand

Larotreni 25&100
Quantity Unit

25mg&100mg*60c/bottle
Manufacturer

Tongmeng (Lao) Pharmaceutical & Food Co., Ltd.（TLPH）

Contents hide

1 Solid Tumors

2 Dosage Modifications

2.1 Dosage modifications for adverse reactions

2.1.1 Body Surface Area (BSA) ≥1 m2

Larotrectinib is a treatment for solid cancers that have a neurotrophic tyrosine receptor kinase (NTRK) gene change. You might have larotrectinib for a solid cancer if: your cancer is locally advanced or advanced (metastatic) surgery to remove the cancer could cause severe health problems.

Solid Tumors

Indicated for adults and pediatric patients with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation, are metastatic or where surgical resection is likely to result in severe morbidity, and have no alternative treatments or have progressed following treatment

100 mg PO BID

Continue until disease progression or until unacceptable toxicity

Dosage Modifications

Dosage modifications for adverse reactions

Body Surface Area (BSA) ≥1 m2
- First occurrence: 75 mg BID
- Second occurrence: 50 mg BID
- Third occurrence: 100 mg qDay
- Unable to tolerate 100 mg qDay: Permanently discontinue