TreatmentTreatment of Chronic Immune or Idiopathic Thrombocytopenic Purpura
Brand name: Elobopa
Generic Name: Eltrombopag
- Form: oral tablet
- Strengths: 25 mg.
TAKE AS DIRETED
Eltrombopag oral tablet is used for long-term treatment. It comes with serious risks if you don’t take it as prescribed.
dosage your doctor prescribes will depend on several factors. These can include:
- the type and severity of the condition you’re using eltrombopag to treat
- your age
- the form of eltrombopag you take
- other medical conditions you may have
- other medication you may be taking
Typically, a doctor will start you on a low dosage and adjust it overtime to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.
Child dosage (ages 1–5 years)
- Starting dosage: 25 mg once per day.
- Dosage changes: Your child’s doctor will test your child’s blood each week to check if this drug is working. Based on your child’s platelet counts, the doctor will increase or decrease your child’s dosage.
- Maximum dosage: 75 mg once per day.
Child dosage (ages under 1 year)
It has not been confirmed that this drug is safe and effective for use in people younger than 1 year for this condition.
Special dosage considerations
- For people with mild to severe liver disease: The typical starting dosage is 25 mg once per day.
- For people with Asian ancestry: The typical starting dosage is 25 mg once per day.
- For people with liver disease and of Asian ancestry: The typical starting dosage is 12.5 mg once per day.
Dosage for low platelet counts from chronic hepatitis C
Adult dosage (ages 18–64 years)
- Starting dosage: 25 mg once per day.
- Dosage changes: Your doctor will test your blood each week to check if this drug is working for you. Based on your platelet counts, your doctor will increase or decrease your dosage every two weeks. They will change your dosage in increments of 25 mg.
- Maximum dosage: 100 mg once per day.
Child dosage (ages 0–17 years)
It has not been confirmed that this drug is safe and effective for use in people younger than 18 years for this condition.
If you stop taking the drug suddenly or don’t take it at all: Your platelet counts may decrease. If your platelet level drops dangerously low, it can cause bleeding. This can lead to serious problems.
If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.
If you take too much: You could cause dangerously high levels of platelets in your body. Symptoms of an overdose of this drug can include:
- blood clots, with symptoms such as:
- pain, redness, and tenderness in your legs
- chest pain
- trouble breathing
- very slow heart rate
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or your local emergency services or go to the nearest emergency room right away.
What to do if you miss a dose: If you miss a dose, wait and take your next scheduled dose. Do not take more than one dose of this drug in one day.
How to tell if the drug is working: You may not be able to feel if the drug is working. Your doctor will test your blood cell levels every week or every other week to check if this drug is working for you. If you’ve reached a stable platelet count, it may mean that this drug is working.
Keep these considerations in mind if your doctor prescribes eltrombopag for you.
- Do not take this drug with food. Take it on an empty stomach. Take it one hour before a meal, or two hours after a meal.
- Take this drug at the same time each day. Take it at the time(s) recommended by your doctor.
This drug comes with several warnings.
Disease progression warning
If you have myelodysplastic syndrome (MDS), this drug can cause your condition to progress to acute myeloid leukemia (AML). For people with MDS, this drug also increases the risk of death. Don’t use this drug if you have MDS.
Blood clots warning
This drug increases platelet counts. This may cause blood clots. If you have other blood clot risk factors, ask your doctor if this drug is safe for you.
This drug may cause cataracts (a clouding of the lens in your eyes). If you already have cataracts, this drug may make your condition worse. Your doctor will give you an eye exam before starting your treatment with this drug. They will also check you for signs of eye problems during treatment. If you develop cataracts, your doctor will lower your dosage or stop your treatment with this drug.
This drug can cause a severe allergic reaction. Symptoms can include:
- trouble breathing
- swelling of your throat or tongue
- skin rash
If you develop these symptoms, call 911 or your local emergency services or go to the nearest emergency room.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).
Food interactions warning
Foods that contain calcium may make eltrombopag less effective. These foods include dairy products, such as milk and cheese. Take this drug at least two hours before eating calcium-rich foods, or four hours after eating calcium-rich foods.
Warnings for people with certain health conditions
For people with myelodysplastic syndrome (MDS): This drug can cause your condition to progress to acute myeloid leukemia (AML). It also raises your risk of death. Don’t use this drug if you have MDS.
For people with liver problems: If you have liver problems or a history of liver disease, you may not be able to process this drug well. This medication may also decrease your liver function, making your liver disease worse. Ask your doctor if this medication is safe for you.
For people with blood clotting disorders: This drug may increase your risk of blood clots. Ask your doctor if this medication is safe for you.
Warnings for other groups
For pregnant people: There haven’t been enough studies done in humans to be certain how this drug might affect a pregnancy. Research in animals has shown negative effects on the pregnancy when the pregnant parent takes the drug. However, animal studies don’t always predict the way humans would respond.
Talk with your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk.
If you become pregnant while taking this drug, call your doctor right away.
For people who are breastfeeding: This medication is not recommended for use while breastfeeding. This drug may pass into breast milk and cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed. You may need to decide whether to stop breastfeeding or stop taking this medication.
For seniors: If you’re older than 65 years, you may have a higher risk of side effects from this drug. Your kidneys and liver may process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk of side effects.
For children: This drug has not been studied in children younger than 1 year with chronic immune thrombocytopenia. It should not be used in children younger than 1 year for this condition.
This drug has not been studied in children younger than 2 years with definitive immunosuppressive therapy-naïve severe aplastic anemia (in combination with other medications). It should not be used in children younger than 2 years for this condition. (Therapy naïve means the condition has not been treated before.)
This drug has not been established as safe or effective for use in children with thrombocytopenia associated with chronic hepatitis C virus infection and refractory severe aplastic anemia. It should not be used on people younger than 18 years with these conditions.
- Store the tablets at room temperature. Keep them at a temperature between 59°F and 86°F (15°C and 30°C).
- Keep this drug in the bottle it came in.
- Do not store this medication in moist or damp areas, such as bathrooms.
- Keep this drug away from light.
A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.
When traveling with your medication:
- Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
- Don’t worry about airport X-ray machines. They cannot harm your medication.
- You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
- Do not put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.
Your doctor should monitor certain health issues during your treatment. This can help make sure you stay safe while you take this drug. These issues include:
- Liver function. A doctor will test your liver function before and during your treatment with this drug. If your liver isn’t working well, the doctor may lower your dosage or stop your treatment with this drug.
- Blood cell and platelet levels. A doctor will test your blood cell levels each week or every other week. This helps the doctor decide your dosage of this drug. They’ll test your blood until your platelet count is stable. Once you’ve reached a stable platelet count, the doctor will test your blood levels once per month.
- Eye function. This drug may cause cataracts. A doctor will do an eye examination before and during your treatment with this drug. If you develop eye problems, the doctor may reduce your dosage or stop your treatment with this drug.
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.
Many insurance companies require prior authorization for this drug. This means that a doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.
There are other drugs available to treat your condition. Some may be better suited for you than others. Talk with your doctor about other drug options that may work for you.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Read more info link: https://www.healthline.com/health/drugs/eltrombopag-oral-tablet#important-considerations