Contents hide 1 About Nirogacestat 1.1 Recommended Dosage About Nirogacestat  Nirogacestat  is an oral, gamma-secretase inhibitor approved to treat adults with progressing desmoid tumors that require systemic treatment. It works by blocking the abnormal protein that signals tumors to grow, helping to stop or slow their progression. Clinical trials showed significant improvements in progression-free survival and tumor response rates, though common side effects include diarrhea, ovarian toxicity, and electrolyte abnormalities.  Recommended Dosage The recommended dosage of OGSIVEO is 150 mg administered orally twice daily until disease progression or unacceptable toxicity. Each 150 mg dose of OGSIVEO consists of three 50 … Continue reading LuciNiro (Nirogacestat)