- Details
- Description
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Packaging Size30t/bottle
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Strength12.5mg
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CompositonAprocitentan
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TreatmentHigh blood pressure (Hypertension)
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FormTablet
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BrandLuciApro
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Quantity Unit12.5mg*30T/Box
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ManufacturerLucius Pharmaceuticals (Lao) Co.,Ltd
About Aprocitentan
Aprocitentan is a once-daily, orally active, dual endothelin receptor antagonist, which inhibits the binding of ET-1 to ETA and ETB receptors. Aprocitentan has a low potential for drug-drug interaction and a mechanism of action that is ideally suited for lowering blood pressure in adult patients whose hypertension is not adequately controlled by other drugs.
Hypertension
Indicated for hypertension in combination with other antihypertensive drugs, to lower blood pressure in adult patients who are not adequately controlled on other drugs
12.5 mg PO qDay
Dosage Modifications
Renal impairment
- Mild to severe (eGFR ≥15 mL/min): No dose adjustment required
- Kidney failure (eGRF <15 mL/min) or hemodialysis: Not recommended
Hepatic impairment
- Mild (Child-Pugh class A): No dose adjustment required
- Moderate or severe (Child-Pugh class B or C): Not recommended
Dosing Considerations
Before initiating and monitoring during treatment
- Confirm a negative pregnancy test in females of reproductive potential before initiating, monthly during treatment, and 1 month after discontinuing
- Measure hemoglobin before initiating and periodically during treatment as clinically indicated
- Measure serum aminotransferase levels and total bilirubin before initiating and periodically during treatment as clinically indicated
- Monitor for signs and symptoms of fluid retention, weight gain, and worsening heart failure
