- Details
- Description
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Packaging Size20t/bottle
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Strength200mg
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CompositonFinerenone
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TreatmentChronic Kidney Disease (CDK)
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FormTablet
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BrandLUCIFINE
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Quantity Unit200mg*20t/Box
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ManufacturerLucius Pharmaceuticals (Lao) Co.,Ltd
About Finerenone
Finerenone is a medication used to reduce the risk of kidney function decline, kidney failure, cardiovascular death, non-fatal heart attacks, and hospitalization for heart failure in adults with chronic kidney disease associated with type 2 diabetes. Finerenone is a non-steroidal mineralocorticoid receptor antagonist (MRA).
Chronic Kidney Disease
Indicated to reduce risk of sustained estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease, cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure in adults with chronic kidney disease (CKD) associated with type 2 diabetes
Starting dose
- Determine starting dose by eGFR (mL/min/1.73m2)
- eGFR ≥60: 20 mg PO qDay
- eGFR 25-60: 10 mg PO qDay
- eGFR <25: Not recommended
- Increase dosage after 4 weeks to the target dose of 20 mg qDay based on eGFR and serum potassium thresholds
Dosage Modifications
Dose adjustment
Dose adjustment based on current serum potassium concentration (mEq/L) and current dose
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Currently taking 10 mg qDay
- ≤4.8 mEq/L: Increase dose to 20 mg qDay; if eGFR has decreased by more than 30% compared to previous measurement, maintain 10 mg dose
- >4.8-5.5 mEq/L: Maintain 10 mg/day
- >5.5 mEq/L: Withhold dose; consider restarting at 10 mg qDay when potassium ≤5 mEq/L
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Currently taking 20 mg qDay
- ≤4.8 mEq/L: Maintain 20 mg qDay
- >4.8-5.5 mEq/L: Maintain 20 mg/day
- >5.5 mEq/L: Withhold dose; restart at 10 mg qDay when potassium ≤5 mEq/L
Renal impairment
- eGFR 15 to <90 mL/min/1.73 m2: No clinically relevant differences in AUC or peak plasma concentration
- Initial dose and adjustments are based on eGFR and serum potassium levels
Hepatic impairment
- Mild or moderate (Child-Pugh A or B): No dosage adjustment recommended
- Severe (Child-Pugh C): Avoid
