Trastuzumab Botidotin

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  • Model Number:
    RL54202506111901
  • Brand Name:
    舒泰莱
  • Origin:
    Original invention from China
  • Small Orders:
    Small batches also available
  • Tags:
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Poster
  • Details
  • Description
  • Packaging Size
    1Bottle/Box
  • Strength
    40mg/Bottle
  • Compositon
    Trastuzumab Botidotin
  • Treatment
    HER2-positive breast cancer (BC)
  • Form
    Injection
  • Brand
    舒泰莱
  • Quantity Unit
    50mg*1Bottle/Box
  • Manufacturer
    KELUN-BIOTECH,China

About trastuzumab botidotin

Trastuzumab botidotin is a differentiated HER2 ADC to treat advanced HER2+ solid tumors. As an innovative HER2 ADC developed by the Company, it conjugates a novel, monomethyl auristatin F (MMAF) derivative (a highly cytotoxic tubulin inhibitor, Duo-5) via a stable, enzyme-cleavable linker to a HER2 monoclonal antibody with a drug-to-antibody-ratio (DAR) of 2. Trastuzumab botidotin specifically binds to HER2 on the surface of tumor cells and is internalized by tumor cells, releasing the toxin molecule Duo-5 inside the cell. Duo-5 induces tumor cell cycle arrest in the G2/M phase, leading to tumor cell apoptosis. After targeting HER2, trastuzumab botidotin can also inhibit the HER2 signaling pathway; it has antibody-dependent cell-mediated cytotoxicity (ADCC) activity.


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