- Details
- Description
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Packaging Size188t/Bottle
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Strength100mg
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CompositonBedaquiline
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TreatmentMultidrug Resistant Pulmonary Tuberculosis
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FormTablet
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BrandLuciBeda
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Quantity Unit100mg*188t/Box
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ManufacturerLucius Pharmaceuticals (Lao) Co.,Ltd
About Bedaquiline
Bedaquiline is used in combination with other medicines to treat pulmonary tuberculosis of the lungs caused by Mycobacterium tuberculosis that is resistant to other medicines (eg, rifampin, isoniazid). Bedaquiline prevents the growth of tuberculosis in the body.
Multidrug Resistant Pulmonary Tuberculosis
Diarylquinoline antimycobacterial indicated as part of combination therapy for pulmonary tuberculosis (TB) due to Mycobacterium tuberculosis resistant to at least rifampin and isoniazid
Only use in combination with at least 3 other drugs to which the patient’s TB isolate has been shown to be susceptible in vitro; if in vitro testing results are unavailable, may be initiated in combination with at least 4 other drugs to which the patient’s TB isolate is likely to be susceptible
Weeks 1-2: 400 mg PO once daily for 2 weeks, THEN
Weeks 3-24: 200 mg PO 3 times/week with at least 48 hr between doses
If treatment is considered necessary beyond 24 weeks, may continue at 200 mg PO 3 times/week
Dosage Modifications
Renal impairment
- Mild-to-moderate: No dosage adjustment required
- Severe or end-stage renal disease requiring hemodialysis or peritoneal dialysis: Use with caution; if used, monitor for adverse reactions of bedaquiline
Hepatic impairment
- Mild or moderate (Child-Pugh A or B): No dosage adjustment required
- Severe (Child-Pugh C): Not studied; use only if benefits outweigh risks
Dosing Considerations
Limitations of use
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Do not use for treatment of
- Latent infection due to Mycobacterium tuberculosis
- Drug-sensitive tuberculosis
- Extra-pulmonary tuberculosis
- Infections caused by nontuberculous mycobacteria
Required testing before administration
- Susceptibility information for background regimen against M tuberculosis isolate if possible
- ECG
- Serum potassium, calcium, and magnesium concentrations
- Liver enzymes
