LuciVande 100 (Vandetanib)

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  • Model Number:
    RL362025060601
  • Brand Name:
    LuciVande 100
  • Origin:
    Generic drug,Laos
  • Small Orders:
    Small batches also available
  • Tags:
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  • Details
  • Description
  • Packaging Size
    30t/bottle
  • Strength
    100mg
  • Compositon
    Vandetanib
  • Treatment
    Medullary Thyroid Cancer
  • Form
    Tablet
  • Brand
    LuciVande 100
  • Quantity Unit
    100mg*30t/Box
  • Manufacturer
    Lucius Pharmaceuticals (Lao) Co.,Ltd

About Vandetanib 

Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients.

Medullary Thyroid Cancer

Indicated for treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease

300 mg PO qDay with or without food

Continued until disease progression or unacceptable toxicity occurs

Dosage Modifications

Dose Reduction

  • Grade ≥3 toxicities: Reduce to 200 mg qDay; then further reduce to 100 mg qDay if necessary
  • Interrupt therapy
    • Corrected QT interval, Fridericia (QTcB) interval >500 msec: Resume at reduce dose once QTcF ≤450 msec
    • Grade ≥3 toxicity: Resume at reduced dose once toxicity resolves to Grade <1
    • Recurrent toxicities: Reduce dose to 100 mg once toxicity resolves to Grade <1, if continued treatment is warranted

Renal impairment

  • CrCl ≥50 mL/min: No dosage adjustment necessary
  • Moderate (CrCl 30 to <50 mL/min): Reduce starting dose to 200 mg PO qDay
  • Severe (CrCl <30 mL/min): Not recommended
  • End-stage renal disease requiring dialysis: Not studied

Hepatic impairment

  • Mild (Child Pugh A): Dose adjustment not described in manufacturer's label
  • Moderate-to-severe (Child-Pugh B or C): Not recommended

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