Generic (Larotrectinib) Larotreni 100

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  • Details
  • Description
  • Packaging Size
    60c
  • Strength
    100mg
  • Compositon
    Larotrectinib
  • Treatment
    Neurotrophic tyrosine receptor kinase (NTRK) gene fusion solid tumors
  • Form
    Capsule
  • Brand
    Larotreni
  • Quantity Unit
    100mg*60c/Box
  • Manufacturer
    Tongmeng (Lao) Pharmaceutical & Food Co., Ltd.(TLPH)

Larotrectinib is a treatment for solid cancers that have a neurotrophic tyrosine receptor kinase (NTRK) gene change. You might have larotrectinib for a solid cancer if: your cancer is locally advanced or advanced (metastatic) surgery to remove the cancer could cause severe health problems.

Solid Tumors

Indicated for adults and pediatric patients with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation, are metastatic or where surgical resection is likely to result in severe morbidity, and have no alternative treatments or have progressed following treatment

100 mg PO BID

Continue until disease progression or until unacceptable toxicity

Dosage Modifications

Dosage modifications for adverse reactions

  • Body Surface Area (BSA) ≥1 m2
    • First occurrence: 75 mg BID
    • Second occurrence: 50 mg BID
    • Third occurrence: 100 mg qDay
    • Unable to tolerate 100 mg qDay: Permanently discontinue

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