- Details
- Description
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Packaging Size30t/bottle
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Strength5mg
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CompositonLemborexant
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TreatmentInsomnia
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FormTablet
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BrandLuciLemb
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Quantity Unit5mg*30t/Box
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ManufacturerLucius Pharmaceuticals (Lao) Co.,Ltd
About Lemborexant
Lemborexant is an orexin receptor antagonist used to treat adult insomnia, specifically difficulty falling asleep and staying asleep. It works by inhibiting the brain's wake-promoting orexin system to initiate and maintain sleep. Common side effects include somnolence (sleepiness) and next-day drowsiness.
Insomnia
Indicated for insomnia characterized by difficulties with sleep onset and/or sleep maintenance
5 mg PO no more than once per night, immediately before going to bed, with at least 7 hr remaining before planned time of awakening
May increase dose to maximum of 10 mg based on clinical response and tolerability
Dosage Modifications
Coadministration with CYP3A inhibitors
- Strong or moderate CYP3A inhibitors: Avoid concomitant use
- Weak CYP3A inhibitors: Not to exceed 5 mg/night
Coadministration with CYP3A inducers
- Strong or moderate CYP3A inducers: Avoid concomitant use
Renal impairment
- Mild, moderate, or severe: No dose adjustment recommended
- Severe: AUC increased; patients may experience increased risk of somnolence
Hepatic impairment
- Mild (Child-Pugh A): No dose adjustment recommended; however, patients may experience an increased risk of somnolence; AUC increased
- Moderate (Child-Pugh B): Not to exceed 5 mg/night; AUC, peak plasma concentration, and half-life increased
- Severe (Child-Pugh C): Not recommended (not studied)
