Generic (Erdafitinib) Edadx

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  • Details
  • Description
  • Packaging Size
  • Strength
  • Compositon
  • Treatment
    urothelial cancer,bladder cancer
  • Form
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  • Manufacturer
    DAXIONG Pharma,Laos PDR

Erdafitinib is used to treat certain types of urothelial cancer (cancer of the lining of the bladder and other parts of the urinary tract) that spread to nearby tissues or other parts of the body that cannot be removed by surgery and has worsened during or after being treated with other chemotherapy medications. Erdafitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Urothelial Carcinoma

Indicated for locally advanced or metastatic urothelial carcinoma that has fibroblast growth factor receptor-2 (FGFR2) or FGFR3 genetic alterations and progressed during or following at least 1 line of prior platinum-containing chemotherapy, including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy

8 mg PO qDay initially; increase to 9 mg PO qDay based on serum phosphate (PO4) levels and tolerability at 14-21 days

Continue until disease progression or unacceptable toxicity

Increase dose to 9 mg qDay if serum phosphate level <5.5 mg/dL and there are no ocular disorders or Grade ≥2 adverse reactions

Dosage Modifications

  • 9 mg/day reduction schedule
    • First: 8 mg/day
    • Second: 6 mg/day
    • Third: 5 mg/day
    • Fourth: 4 mg/day
    • Fifth: Stop drug if fifth reduction needed
  • 8 mg/day reduction schedule
    • First: 6 mg/day
    • Second: 5 mg/day
    • Third: 4 mg/day
    • Fourth: Stop drug if fourth reduction needed