Generic (Eltrombopag) ELTROMDX 50

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  • Treatment
    Chronic Immune Thrombocytopenia (ITP),Severe Aplastic Anemia,Chronic Hepatitis C-associated Thrombocytopenia
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  • Manufacturer
    BIGBEAR Pharma,Laos PDR

Eltrombopag is used to  treat thrombocytopenia (a low blood platelet count) in adults and children with chronic immune thrombocytopenic purpura that did not get better with other treatment.

Chronic Immune Thrombocytopenia (ITP)

Indicated in patients with insufficient response to corticosteroids, immunoglobulins, or splenectomy

Use only in patients with ITP whose clinical condition increases bleeding risk

Initial: 50 mg PO qDay

Maintenance: Adjust dose to achieve and maintain platelet count (Plt) >50 x 10^9/L to reduce risk of bleeding; not to exceed 75 mg/day

Chronic Hepatitis C-associated Thrombocytopenia

Indicated to allow initiation and maintenance of interferon-based therapy

Initial: 25 mg PO qDay

Adjust dose in 25 mg increments q2weeks PRN to achieve target platelet count required to initiate/maintain antiviral therapy with pegylated interferon and ribavirin; not to exceed 100 mg/day

During antiviral therapy, adjust dose to avoid dose reductions of peginterferon

Severe Aplastic Anemia

First-line therapy

  • First-line treatment, in combination with standard immunosuppressive therapy, for patients with severe aplastic anemia (SAA)
  • Initial dose: 150 mg PO qDay for 6 months
  • Do not exceed initial dose; total duration is 6 months

Refractory SAA

  • Indicated for SAA in patients who fail to respond adequately to at least 1 prior immunosuppressive therapy
  • Initial dose: 50 mg PO qDay
  • Adjust dose in 50-mg increments q2Weeks PRN to achieve target Plt ≥50 x 10^9/L as necessary; not exceed 150 mg/day; may take up to 16 weeks for hematologic response