Anti-cancer means used against or tending to arrest or prevent cancer. Anti-cancer drugs, also called antineoplastic drugs, are any drugs that are effective in the treatment of malignant or cancerous disease. There are several major classes of anti-cancer drugs, such as: - Alkylating agents: drugs that damage DNA and prevent cancer cells from dividing - Antimetabolites: drugs that interfere with DNA synthesis and block cell growth - Natural products: drugs derived from plants, animals, or microorganisms that have anti-cancer properties - Hormones: drugs that modify hormone levels and affect hormone-dependent cancers There are also other types of anti-cancer treatments, such as surgery, radiation therapy, immunotherapy, targeted therapy, and stem cell transplant.
Chronic lymphocytic leukemia (CLL) is a type of blood cancer that begins in the bone marrow，Can progress either slowly or quickly depending on the form it takes.Current therapies do not offer patients a cure for CLL, but there are treatments that help manage the disease. Chemotherapy and drug therapy, including targeted therapy…
Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium. Obesity and having metabolic syndrome may increase the risk of endometrial cancer. Taking tamoxifen for breast cancer or taking estrogen alone (without progesterone) can increase the risk of endometrial cancer. Targeted therapy is used…
MET, also known as the hepatocyte growth factor receptor (HGFR), is a protein that is involved in cellular growth, survival, and migration. In some cancers, the MET gene may become altered or amplified, leading to increased MET signaling and contributing to tumor growth and progression. Several targeted therapies have been developed or are under investigation for the treatment of MET-positive…
There have been several targeted therapies under development for the treatment of cancers with KRAS mutations. Sotorasib[1] One of the most promising targeted therapies for KRAS-mutant cancers is sotorasib (also known as AMG 510). Sotorasib specifically targets the KRAS G12C mutation, which is found in a subset of non-small cell…
ALK-positive non-small cell lung cancer (NSCLC) is a subtype of lung cancer characterized by the presence of an abnormal ALK gene fusion. Targeted therapies have been developed to specifically inhibit the activity of the ALK protein, which can help to control tumor growth and progression. The use of tyrosine kinase inhibitors (TKIs) has led to significantly…
There are several targeted drugs that can be used for the treatment of thrombocytopenia, which is a condition characterized by low platelet count. These drugs work by stimulating platelet production or preventing platelet destruction. Some examples include: Thrombopoietin (TPO) receptor agonists: These drugs, such as Eltrombopag and Romiplostim, stimulate the production of platelets by binding to…
There are several targeted drugs that are used for the treatment of bladder cancer. Some of the commonly used targeted drugs include: Immune checkpoint inhibitors Pembrolizumab and Atezolizumab are immune checkpoint inhibitors that are used to treat advanced bladder cancer that has spread to other parts of the body. Pembrolizumab[1]…
BRAF V600 mutation-positive advanced non-small cell lung cancer (NSCLC) can be treated with targeted therapies that specifically inhibit the BRAF V600 mutation. These include: Dabrafenib[1] Dabrafenib is a selective inhibitor of the BRAF kinase that has been shown to be effective in treating NSCLC patients with the BRAF V600E mutation. It works by blocking the activity…
Breast cancer can be classified into different subtypes based on the presence or absence of certain receptors, such as hormone receptors (estrogen and progesterone) and human epidermal growth factor receptor 2 (HER2). HER2-negative breast cancers do not overexpress the HER2 protein, and as such, treatments targeting HER2, like trastuzumab (Herceptin), are not effective for…
Myelofibrosis is a rare bone marrow disorder that disrupts the body's normal production of blood cells. Treatment for myelofibrosis depends on the severity and symptoms of the disease. Some of the drugs used in the treatment of myelofibrosis include: JAK inhibitors These drugs target the Janus kinase (JAK) pathway, which…
The main targeted drugs for multiple myeloma(MM). Targeted therapy drugs work by targeting specific proteins or processes in cancer cells while causing less damage to normal cells.Some targeted drugs used for multiple myeloma include: Proteasome inhibitors These drugs inhibit the protein complex called proteasome, which is responsible for degrading unwanted proteins…
Targeted therapies are drugs that specifically target certain proteins or genetic mutations in cancer cells, which can help to slow down or stop their growth. In cholangiocarcinoma, some of the targeted therapies that have been studied or used include: FGFR inhibitors Some cholangiocarcinomas have alterations in the FGFR2 gene. Drugs that target these…
The main targeted therapies for Acute Myeloid Leukemia (AML) include: FLT3 inhibitors For AML with FLT3 mutations, such as midostaurin, gilteritinib, etc. These target the FLT3 tyrosine kinase. Midostaurin[1] On April 28, 2017, the U.S. Food and Drug Administration approved midostaurin (RYDAPT, Novartis Pharmaceuticals Corp.) for the treatment of adult patients with newly diagnosed acute myeloid leukemia…
Unlocking Global Health Opportunities: Mitotane (MITODX)
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